Oxycodone and acetaminophen tablets may boost the neuromuscular-blocking action of skeletal muscle mass relaxants and produce an increase in the degree of respiratory depression.

Inform feminine patients of reproductive potential that prolonged use of oxycodone and acetaminophen tablets during pregnancy may lead to neonatal opioid withdrawal syndrome, which may be life-threatening if not regarded and treated [see WARNINGS, PRECAUTIONS; PREGNANCY].

Infertility Use of opioids for an extended period of time may possibly cause reduced fertility in women and males of reproductive potential. It's not at all identified irrespective of whether these effects on fertility are reversible [see ADVERSE REACTIONS].

Parenteral drug abuse is commonly related with transmission of infectious diseases including hepatitis and HIV.

The precise mechanism of the analgesic action is unknown. Having said that, particular CNS opioid receptors for endogenous compounds with opioid-like action have been determined through the brain and spinal cord and are imagined to Perform a role during the analgesic effects of this drug.

Exceptional cases of agranulocytosis have likewise been related with acetaminophen use. In high doses, the most really serious adverse effect can be a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may manifest.

Safety and effectiveness of oxycodone and acetaminophen tablets in pediatric patients have not been set up.

The oxycodone in oxycodone and acetaminophen tablets may increase the frequency of seizures in patients with seizure disorders, and may boost the risk of seizures happening in other clinical options affiliated with seizures.

The majority of the conditions of liver injuries are involved with the usage of acetaminophen at doses that exceed four,000 mg every day, and infrequently require much more than just one acetaminophen-containing product or service.

Observe newborns for signs of neonatal opioid withdrawal syndrome and deal with appropriately. Recommend pregnant women making use of opioids for the prolonged period of your risk of neonatal opioid withdrawal syndrome and ensure that proper treatment will probably be readily available [see PRECAUTIONS; INFORMATION FOR PATIENTS/CAREGIVERS, PREGNANCY].

Infants born to mothers bodily dependent on opioids will also be physically dependent and should show respiratory difficulties and withdrawal signs [see PRECAUTIONS; PREGNANCY].

Infertility Inform patients that usage of opioids for an extended period of time may well cause decreased fertility. It is not known whether these effects on fertility are reversible [see ADVERSE REACTIONS].

In experiments executed with the National Toxicology Software, fertility assessments with acetaminophen have been concluded in Swiss CD-one mice by way of a ongoing breeding study. There were no effects on fertility parameters percocet functions in mice consuming nearly 1.7 times the MHDD of acetaminophen, based on a system surface area location comparison. Although there was no effect on sperm motility or sperm density within the epididymis, there was a significant increase in the percentage of abnormal sperm in mice consuming 1.

The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone.